- Title
- Brain ageing in schizophrenia: evidence from 26 international cohorts via the ENIGMA Schizophrenia consortium
- Creator
- Constantinides, Constantinos; Han, Laura K. M.; Bustillo, Juan; Bykhovski, Oleg; Calhoun, Vince; Carr, Vaughan; Catts, Stanley; Chung, Young-Chul; Crespo-Facorro, Benedicto; Díaz-Caneja, Covadonga M.; Donohoe, Gary; Plessis, Stefan Du; Alloza, Clara; Edmond, Jesse; Ehrlich, Stefan; Emsley, R; Eyler, LT; Fuentes-Claramonte, P; Georgiadis, F; Green, M; Guerrero-Pedraza, A; Ha, M; Hahn, T; Antonucci, Linda Antonella; Henskens, Frans A.; Holleran, L; Homan, S; Homan, P; Jahanshad, N; Janssen, J; Ji, E; Kaiser, S; Kaleda, V; Kim, M; Arango, Celso; Kim, W-S; Kirschner, M; Kochunov, P; Kwak, YB; Kwon, JS; Lebedeva, I; Liu, J; Mitchie, Patricia; Michielse, S; Mothersill, D; Ayesa-Arriola, Rosa; Mowry, B; de la Foz, VO-G; Pantelis, C; Pergola, G; Piras, F; Pomarol-Clotet, E; Preda, A; Quidé, Y; Rasser, Paul E.; Rootes-Murdy, K; Banaj, Nerisa; Salvador, R; Sangiuliano, M; Sarró, S; Schall, Ulrich; Schmidt, A; Scott, Rodney J.; Selvaggi, P; Sim, K; Skoch, A; Spalletta, G; Bertolino, Alessandro; Spaniel, F; Thomopoulos, SI; Tomecek, D; Tomyshev, AS; Tordesillas-Gutiérrez, D; van Amelsvoort, T; Vázquez-Bourgon, J; Vecchio, D; Voineskos, A; Weickert, CS; Borgwardt, Stefan; Weickert, T; Thompson, PM; Schmaal, L; van Erp, TGM; Turner, J; Cole, JH; ENIGMA Schizophrenia Consortium,; Du Plessis, S; Bin Kwak, Y; Dima, D; Bruggemann, Jason; Walton, E
- Relation
- Molecular Psychiatry Vol. 28, Issue 3, p. 1201-1209
- Publisher Link
- http://dx.doi.org/10.1038/s41380-022-01897-w
- Publisher
- Nature Publishing Group
- Resource Type
- journal article
- Date
- 2023
- Description
- Schizophrenia (SZ) is associated with an increased risk of life-long cognitive impairments, age-related chronic disease, and premature mortality. We investigated evidence for advanced brain ageing in adult SZ patients, and whether this was associated with clinical characteristics in a prospective meta-analytic study conducted by the ENIGMA Schizophrenia Working Group. The study included data from 26 cohorts worldwide, with a total of 2803 SZ patients (mean age 34.2 years; range 18-72 years; 67% male) and 2598 healthy controls (mean age 33.8 years, range 18-73 years, 55% male). Brain-predicted age was individually estimated using a model trained on independent data based on 68 measures of cortical thickness and surface area, 7 subcortical volumes, lateral ventricular volumes and total intracranial volume, all derived from T1-weighted brain magnetic resonance imaging (MRI) scans. Deviations from a healthy brain ageing trajectory were assessed by the difference between brain-predicted age and chronological age (brain-predicted age difference [brain-PAD]). On average, SZ patients showed a higher brain-PAD of +3.55 years (95% CI: 2.91, 4.19; I2 = 57.53%) compared to controls, after adjusting for age, sex and site (Cohen's d = 0.48). Among SZ patients, brain-PAD was not associated with specific clinical characteristics (age of onset, duration of illness, symptom severity, or antipsychotic use and dose). This large-scale collaborative study suggests advanced structural brain ageing in SZ. Longitudinal studies of SZ and a range of mental and somatic health outcomes will help to further evaluate the clinical implications of increased brain-PAD and its ability to be influenced by interventions.
- Subject
- schizophrenia; brain; aging; patients
- Identifier
- http://hdl.handle.net/1959.13/1485329
- Identifier
- uon:51559
- Identifier
- ISSN:1359-4184
- Rights
- x
- Language
- eng
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